In this study, silver sulfadiazine (SSD) loaded Poly ([Formula: see text]-caprolactone)/Poly (ethylene oxide) (PCL/PEO) nanofiber patches were prepared via electrospinning method for topical drug delivery applications. SSD was loaded for the first time into PCL/PEO nanofibers. Nanofiber patches were characterized by Attenuated Total Reflectance Infrared Spectroscopy (FTIR-ATR) to check the presence of chemical bonding between SSD and polymer matrix. The surface morphology of the nanofibers was observed by Scanning Electron Microscopy (SEM). SEM images showed that uniform and smooth composite nanofibers were obtained. The diameter of the nanofibers decreased with the addition of SSD. X-Ray Diffraction (XRD) analysis was carried out to examine the crystallinity of composite nanofiber patches. Energy dispersive spectroscopy (EDS) analysis was performed to confirm Ag and S contents in the SSD loaded composite nanofibers and EDS Mapping was used to show the homogeneous distribution of SSD in the fiber structure. In order to investigate the release and solubility properties of SSD, an unused buffer solution; Water/Propylene Glycol/Phosphoric Acid (82:16:2) was prepared. The release of SSD was performed in this buffer and the release amount of SSD was calculated by UV-Visible Spectrophotometer. Thereby, SSD containing PCL/PEO composite nanofiber carriers were electrospun to achieve the enhancement in solubility, effective drug release and efficient drug loading of SSD. All experimental studies demonstrated that SSD loaded PCL/PEO composite nanofibers have great potential to be used in topical drug delivery applications.

中文翻译：

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用于局部给药的磺胺嘧啶银负载聚（ε-己内酯）/聚（环氧乙烷）复合纳米纤维

在这项研究中，通过静电纺丝法制备了负载磺胺嘧啶银 (SSD) 的聚（[分子式：参见正文]-己内酯）/聚（环氧乙烷）（PCL/PEO）纳米纤维贴片，用于局部给药应用。SSD 首次加载到 PCL/PEO 纳米纤维中。纳米纤维贴片通过衰减全反射红外光谱 (FTIR-ATR) 进行表征，以检查 SSD 和聚合物基质之间是否存在化学键。通过扫描电子显微镜（SEM）观察纳米纤维的表面形态。SEM 图像显示，获得了均匀光滑的复合纳米纤维。纳米纤维的直径随着 SSD 的加入而减小。进行 X 射线衍射 (XRD) 分析以检查复合纳米纤维贴片的结晶度。进行能量色散光谱 (EDS) 分析以确认负载 SSD 的复合纳米纤维中的 Ag 和 S 含量，并使用 EDS Mapping 显示 SSD 在纤维结构中的均匀分布。为了研究 SSD 的释放和溶解特性，一种未使用的缓冲溶液；制备水/丙二醇/磷酸(82:16:2)。SSD的释放是在这个缓冲区中进行的，SSD的释放量是通过紫外可见分光光度计计算的。因此，对含有 PCL/PEO 复合纳米纤维载体的 SSD 进行静电纺丝，以实现 SSD 溶解度、有效药物释放和有效载药的增强。所有实验研究表明，负载 SSD 的 PCL/PEO 复合纳米纤维在局部给药应用中具有巨大的潜力。