Agelastatin A, an alkaloid originally isolated from the marine sponge Agelas dendromorpha, has long been an attractive target of chemical synthesis due to its significant biological activity and unique chemical structure. The synthetic approaches to the agelastatin alkaloid have demonstrated the advances of new methodologies and strategies for accessing a highly functionalized polycyclic nitrogen heterocycle. The present article reviews synthetic endeavors on agelastatin A that have been made by various synthetic chemists as well as biological studies on the natural product and its analogues aimed at the development of medicinal resources.

中文翻译：

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大自然赐予的生物活性海洋杂环菌Agelastatin A的化学合成及生物学研究

Agelastatin A是一种最初从海洋海绵Agelas dendromorpha中分离出的生物碱，由于其显着的生物学活性和独特的化学结构，长期以来一直是化学合成的有吸引力的目标。合成接近所述agelastatin生物碱已经证实的新的方法以及用于访问一个高度官能化的多环氮杂环策略的进展。本文概述了由各种合成化学家对Alastlastatin A进行的合成研究，以及针对天然产物及其类似物的生物学研究，旨在开发药用资源。