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Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy
Journal of Biological Research-Thessaloniki ( IF 3.3 ) Pub Date : 2018-02-05 , DOI: 10.1186/s40709-018-0075-5
Umesh Chandra Halder

Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients’ death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-integrated hematopoietic, erythroid and red blood cells. Here, HIV specific receptors trap circulating viruses that enter erythrocyte cytoplasm and form inactive integration complex. This model depicts easy, effective removal of circulating HIV without any adverse effect.

中文翻译:

骨髓干细胞破坏循环中的HIV:一种假设的治疗策略

人类免疫缺陷病毒(HIV)仍然对人类生命构成神秘的威胁。该病毒已成功绕过抗逆转录病毒疗法导致患者死亡。循环病毒对疾病的后果非常重要。该假设提出了利用受体整合的造血,红系和红细胞的治疗策略。在这里,HIV特异性受体会捕获进入红细胞细胞质并形成无活性整合复合物的循环病毒。该模型描述了轻松有效地清除循环中的HIV而没有任何不利影响的方法。
更新日期:2018-02-05
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