Over the past decade, mesenchymal stromal cells (MSCs) found in the bone marrow microenvironment have been considered to be important candidates in cellular therapy. However, the application of MSCs in clinical settings is limited by the difficulty and low efficiency associated with the separation of MSCs from the bone marrow. Therefore, distinct sources of MSCs have been extensively explored. Adipose-derived stromal cells (ASCs), a cell line similar to MSCs, have been identified as a promising source. ASCs have become increasingly popular in many fields, as they can be conveniently extracted from fat tissue. This review focuses on the properties of ASCs in hematopoietic regulation and the underlying mechanisms, as well as the current applications and future perspectives in ASC-based therapy.

中文翻译：

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脂肪来源的基质细胞在造血调节中的作用

在过去的十年中，在骨髓微环境中发现的间充质基质细胞（MSC）被认为是细胞治疗的重要候选药物。然而，MSCs在临床环境中的应用受到与从骨髓分离MSCs相关的困难和低效率的限制。因此，已经广泛地探索了MSC的不同来源。脂肪来源的基质细胞（ASC）是一种与MSC相似的细胞系，已被确认为有希望的来源。由于ASC可以方便地从脂肪组织中提取，因此在许多领域变得越来越流行。这篇综述着重于ASC在造血调节中的特性和潜在机制，以及基于ASC的治疗的当前应用和未来前景。