Nanotechnology is a frequent treatment for cancer. Nanomaterials are the vehicles which deliver drugs in smaller but equally effective quantities. The aim of this investigation is to synthesize gold nanoparticles, functionalize them for the transportation of cisplatin and release them to the cancer-affected area. They have the same cytotoxicity as conventional treatments but with the smallest effective quantity of cisplatin. We synthesized spherical gold nanoparticles using the Turkevich method. We functionalized them with polyethylene glycol and cisplatin, adapting the method used by Sun. Using electronic transmission microscopy, Dynamic Light Scattering and potential Z, we analyzed the size, hydrodynamic size, shape and stability of the synthesized nanoparticles. We analyzed their composition using images from scanning electronic microscopy to carry out energy dispersive spectroscopy measurements, ultraviolet/visible light spectroscopy and Fourier transform infrared spectroscopy. We used MTT tests to find cell viability and obtained the IC50 of the different cancer cell lines. The synthesized nanoparticles were spherical in shape and, after functionalization, were of the core–shell type. They contain approximately 7% cisplatin. The IC50 obtained diminished approximately 7 times (compared to the IC50 of cisplatin used alone) when using the gold nanoparticles. Therefore, this study opens up the possibility of an alternative way of transporting the cisplatin anticancer drug, using gold nanoparticles. It decreases the dose and has the same effect as the cisplatin, so that the undesired side effects decrease.

中文翻译：

---

以金纳米颗粒为载体减少顺铂的有效剂量

纳米技术是癌症的常见治疗方法。纳米材料是以较小但有效量输送药物的媒介。这项研究的目的是合成金纳米颗粒，将其功能化以运输顺铂并将其释放到受癌症影响的区域。它们具有与常规治疗相同的细胞毒性，但顺铂的有效量最小。我们使用Turkevich方法合成了球形金纳米颗粒。我们使用聚乙二醇和顺铂对它们进行功能化，以适应Sun使用的方法。使用电子透射显微镜，动态光散射和电势Z，我们分析了合成纳米粒子的尺寸，流体动力学尺寸，形状和稳定性。我们使用来自扫描电子显微镜的图像分析了它们的成分，以进行能量色散光谱测量，紫外/可见光光谱和傅里叶变换红外光谱。我们使用MTT测试来发现细胞活力，并获得了不同癌细胞系的IC50。合成的纳米颗粒为球形，功能化后为核-壳型。它们含有约7％的顺铂。使用金纳米颗粒时，获得的IC50降低了约7倍（与单独使用的顺铂的IC50相比）。因此，这项研究开辟了使用金纳米颗粒运输顺铂抗癌药物的另一种方法的可能性。它减少了剂量，并具有与顺铂相同的作用，从而减少了不良副作用。