ABSTRACT

Herein, new microspheres were successfully fabricated from pentaerythritol tetrakis(3-mercaptopropionate) as model monomer and hexachlorocyclotriphosphazene as crosslinker using a single-step via precipitation polymerization method. Trimethoprim was chosen as the model antibiotic drug for drug release and antimicrobial activity studies. The percent of drug loading and drug entrapment efficiency of the microspheres was calculated to be 0.85% and 42.2%. According to correlation coefficients, the release kinetic was found to be Higuchi kinetic model and the release mechanism was non-Fickian model for microspheres. The drug-loaded microspheres exhibited excellent bacterial inhibition against gram-positive (Staphylococcus aureus and Bacillus subtilis) and gram-negative (Escherichia coli) bacteria.

摘要

在此，通过沉淀聚合法一步一步从季戊四醇四（3-巯基丙酸酯）作为模型单体和六氯环三磷腈作为交联剂成功地制备了新的微球。选择甲氧苄啶作为模型抗生素药物，用于药物释放和抗菌活性研究。计算的微球载药量和药物截留效率的百分比分别为0.85％和42.2％。根据相关系数，发现微球的释放动力学为Higuchi动力学模型，释放机理为非菲克模型。载药微球对革兰氏阳性菌（金黄色葡萄球菌和枯草芽孢杆菌）和革兰氏阴性菌（革兰氏阴性菌）表现出优异的抑菌作用。大肠杆菌）细菌。