ABSTRACT

In our work, reversible addition-fragmentation chain transfer (RAFT)/carbon nanotube (CNT)/acrylic acid (AA)/acrylamide (AAm) nanocomposite was synthesized by living radical polymerization. The structure and surface morphology of the synthesized RAFT-CNT-Hydrogel nanocomposites were analyzed by FTIR, ¹HNMR, SEM, TEM, XRD, and TGA/DTG techniques. The results indicated that PAA/AAm chains grafted with CNT by RAFT polymerization. RAFT-CNT-Hydrogel nanocomposites for drug release investigated in different buffers resulted in a strong pH-sensitive behavior. In total, the obtained hydrogel drug-delivery systems are presented a proper effect versus stomach cancer in vitro and in vivo, and it can be used as candidates for controlled release of anticancer drugs in stomach with exalted remedial agents.

摘要

在我们的工作中，通过活性自由基聚合合成了可逆的加成-断裂链转移（RAFT）/碳纳米管（CNT）/丙烯酸（AA）/丙烯酰胺（AAm）纳米复合材料。通过FTIR，¹ HNMR，SEM，TEM，XRD和TGA / DTG技术分析了合成的RAFT-CNT-Hydrogel纳米复合材料的结构和表面形态。结果表明，通过RAFT聚合反应，PAA / AAm链与CNT接枝。在不同缓冲液中研究的用于药物释放的RAFT-CNT-Hydrogel纳米复合材料具有很强的pH敏感性。总体而言，获得的水凝胶药物递送系统在体外和体内均表现出对抗胃癌的适当作用，并且可以用作抗癌药物与高水平的补救剂一起在胃中受控释放的候选药物。