Interference screws are commonly used for the treatment of ruptured ligaments. The interference screws are often constructed from polylactic acid (PLA). In this study, a melt blend of PLA, polyethylene glycol (PEG) and hydroxyapatite (HA) was investigated for use in interference screws. For this purpose, mechanical properties, differential scanning calorimetry (DSC), degradation rate, pH change, water contact angle, morphology, cytotoxicity, and cell adhesion on the specimens were investigated. According to the tensile test results, by mixing various levels of PLA, PEG, and HA, mechanical properties of the resulting composite can be kept constant or even improved in comparison with pure PLA. DSC proved the miscibility of components and provided a softer product after adding PEG to the mixture. The weight loss of samples was investigated over a period of 7 months and the results indicated an increase in the degradation rate by increasing PEG level. pH changes were also investigated indicating no significant change in pH. The contact angle test showed an increase in the hydrophilic nature of all specimens with increasing PEG and HA levels. Surface morphology was studied by scanning electron microscope (SEM) and the results showed an increase in toughness with increasing PEG level. 2 µm HA particles and HA agglomeration in some areas were clearly observed in the SEM micrographs. According to the MTT test, none of the samples caused cell death, and results also showed good and spread cell adhesion to the specimens.

干涉螺钉通常用于治疗韧带破裂。干涉螺钉通常由聚乳酸（PLA）制成。在这项研究中，研究了PLA，聚乙二醇（PEG）和羟基磷灰石（HA）的熔融共混物以用于干涉螺钉。为此，研究了机械性能，差示扫描量热法（DSC），降解率，pH值变化，水接触角，形态，细胞毒性和细胞在样品上的粘附性。根据拉伸试验结果，通过混合各种含量的PLA，PEG和HA，与​​纯PLA相比，所得复合材料的机械性能可以保持恒定甚至提高。DSC证明了组分的可混溶性，并在将PEG加入混合物后提供了较软的产品。在7个月的时间内研究了样品的失重，结果表明通过增加PEG水平可提高降解速率。还研究了pH变化，表明pH没有明显变化。接触角测试表明，随着PEG和HA含量的增加，所有样品的亲水性均增加。用扫描电子显微镜（SEM）研究了表面形态，结果表明，韧性随着PEG含量的增加而增加。在SEM显微图中清楚地观察到2 µm的HA颗粒和某些区域的HA团聚。根据MTT测试，没有一个样品引起细胞死亡，并且结果还显示了良好的和分散的细胞对样品的粘附。还研究了pH变化，表明pH没有明显变化。接触角测试表明，随着PEG和HA含量的增加，所有样品的亲水性均增加。用扫描电子显微镜（SEM）研究了表面形态，结果表明，韧性随着PEG含量的增加而增加。在SEM显微图中清楚地观察到2 µm的HA颗粒和某些区域的HA团聚。根据MTT测试，没有一个样品引起细胞死亡，并且结果还显示了良好的和分散的细胞对样品的粘附。还研究了pH变化，表明pH没有明显变化。接触角测试表明，随着PEG和HA含量的增加，所有样品的亲水性均增加。用扫描电子显微镜（SEM）研究了表面形态，结果表明，韧性随着PEG含量的增加而增加。在SEM显微图中清楚地观察到2 µm的HA颗粒和某些区域的HA团聚。根据MTT测试，没有一个样品引起细胞死亡，并且结果还显示了良好的和分散的细胞对样品的粘附。用扫描电子显微镜（SEM）研究了表面形态，结果表明，韧性随着PEG含量的增加而增加。在SEM显微图中清楚地观察到2 µm的HA颗粒和某些区域的HA团聚。根据MTT测试，没有一个样品引起细胞死亡，并且结果还显示了良好的和分散的细胞对样品的粘附。用扫描电子显微镜（SEM）研究了表面形态，结果表明，韧性随着PEG含量的增加而增加。在SEM显微图中清楚地观察到2 µm的HA颗粒和某些区域的HA团聚。根据MTT测试，没有一个样品引起细胞死亡，并且结果还显示了良好的和分散的细胞对样品的粘附。