Carboxy-methyl-cellulose (CMC) hydrogels, prepared in the presence of a crosslinker and photoinitiator, were reinforced with 3.7 wt% electrospun PLA fibers to create CMC hydrogel composites. To improve fiber-matrix adhesion, electrospun fiber mats based on hybrids of PLA and amphiphilic block copolymer (BCP) poly(D,L-lactide)-block-poly[2-(dimethylamino)ethyl methacrylate] (PLA-b-PDMAEMA) were produced. The presence of PDMAEMA at the fiber surface induced hydrophilic surface properties, which could be controlled by varying the PDMAEMA chain length. PDMAEMA was quaternized and co-electrospun with PLA fibers, which further enhanced the interaction between fibers and hydrogel matrix via ionic interactions. Physicochemical properties of the electrospun fiber mats and their CMC hydrogel based composites were assessed and revealed a nearly two orders of magnitude increase in modulus. Continuous electrospun fiber mats were chopped into discontinuous fibers to create short fiber reinforced CMC hydrogels. Rheological properties of these reinforced hydrogels incorporating 0.5 wt% discontinuous fibers were evaluated and showed potential as injectable composite systems for biomedical applications.

在交联剂和光引发剂存在下制备的羧甲基纤维素（CMC）水凝胶用3.7 wt％的电纺PLA纤维增强，以生成CMC水凝胶复合材料。为了提高纤维与基质的粘合力，基于PLA和两亲嵌段共聚物（BCP）聚（D，L-丙交酯）-嵌段-聚[甲基丙烯酸2-（二甲氨基）乙酯]（PLA-b-PDMAEMA）的混合物的电纺纤维毡被生产了。PDMAEMA在纤维表面的存在会引起亲水性表面性质，这可以通过改变PDMAEMA链长来控制。PDMAEMA进行季并与PLA纤维，其进一步增强纤维和水凝胶基体之间的相互作用共同电纺丝通过离子相互作用。评估了电纺纤维毡及其基于CMC水凝胶的复合材料的理化性质，发现其模量增加了近两个数量级。将连续的电纺纤维毡切成不连续的纤维，以形成短纤维增强的CMC水凝胶。评估了这些掺有0.5 wt％不连续纤维的增强水凝胶的流变特性，并显示出了作为生物医学应用的可注射复合系统的潜力。