Abstract Per- and polyfluoroalkyl substances, a group of fluoro-surfactants widely detected in the environment, wildlife, and humans, have been linked to adverse health effects. A growing body of literature has addressed their effects on obesity, diabetes and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. This review summarizes the brief historical use and chemistry of per- and polyfluoroalkyl substances, routes of human exposure, as well as the epidemiologic evidence for associations between exposure to per- and polyfluoroalkyl substances and the development of obesity, diabetes and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis. We identified 22 studies on obesity and 32 studies on diabetes, while only 1 study was found for non-alcoholic fatty liver disease/non-alcoholic steatohepatitis by searching PubMed for human studies. Approximately two-third of studies reported positive associations between per- and polyfluoroalkyl substances exposure and the prevalence of obesity and/or type 2 diabetes. Causal links between per- and polyfluoroalkyl substances and obesity, diabetes and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis, however, require further large-scale prospective cohort studies combined with mechanistic laboratory studies to better assess these associations.

中文翻译：

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全氟和多氟烷基物质与肥胖、2 型糖尿病和非酒精性脂肪肝：流行病学调查结果回顾

摘要 全氟和多氟烷基物质是在环境、野生动物和人类中广泛检测到的一组含氟表面活性剂，与不良健康影响有关。越来越多的文献论述了它们对肥胖、糖尿病和非酒精性脂肪性肝病/非酒精性脂肪性肝炎的影响。本综述总结了全氟和多氟烷基物质的简要历史用途和化学、人类暴露途径，以及全氟和多氟烷基物质暴露与肥胖、糖尿病和非酒精性脂肪肝发展之间关联的流行病学证据。疾病/非酒精性脂肪性肝炎。我们确定了 22 项关于肥胖的研究和 32 项关于糖尿病的研究，而通过在 PubMed 中搜索人体研究，仅发现 1 项针对非酒精性脂肪性肝病/非酒精性脂肪性肝炎的研究。大约三分之二的研究报告了全氟和多氟烷基物质暴露与肥胖和/或 2 型糖尿病患病率之间的正相关。然而，全氟和多氟烷基物质与肥胖、糖尿病和非酒精性脂肪性肝病/非酒精性脂肪性肝炎之间的因果关系需要进一步的大规模前瞻性队列研究与机械实验室研究相结合，以更好地评估这些关联。