Abstract This research is conducted to determine the larvicidal, repellent and pathological effects of fruit extracts of C. colocynthis on malaria vector mosquito, Anopheles stephensi Liston, 1901. The fruit water and ethanol extract of C. colocynthis were concentrated for larvicidal and repellent activities on human volunteer against An. stephensi. The temephos larvicide was tested as the positive control. A concentration of 300 mg/L had full-scale mortality and the most toxic effect. The LC50 and LC90 values of C. colocynthis water and ethanol extracts were 180and 283 mg/L, respectively. The LC50 and LC90 values of temephos were 0.2706 and 1.6932 mg/L, respectively. The ED50 and ED90 values of the plant extract were 0.2 and 1.3 mg/cm2, respectively. Thin sections from treated larvae exhibited gross histopathologic effects of C. colocynthis fruit extracts on gut epithelial cell layer by vacuolization of foregut cuboidal and midgut columnar cells. This study suggested that the fruit extracts of C. colocynthis had significant larvicidal and repellent activity to be used as an ideal approach to control the malaria vector mosquito.

中文翻译：

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Citrullus colocynthis 对疟疾载体的杀幼虫、驱虫和组织病理学作用

摘要 本研究旨在确定 C. colocynthis 果实提取物对疟疾媒介蚊子 (Anopheles stephensi Liston, 1901) 的杀幼虫、驱虫和病理作用。C. colocynthis 的果实水和乙醇提取物被浓缩用于对疟原虫的幼虫和驱虫活性。人类志愿者对抗 An。斯蒂芬西。杀虫磷杀幼虫剂被测试为阳性对照。300 mg/L 的浓度具有全面的死亡率和最大的毒性作用。C. colocynthis 水和乙醇提取物的 LC50 和 LC90 值分别为 180 和 283 mg/L。temephos 的 LC50 和 LC90 值分别为 0.2706 和 1.6932 mg/L。植物提取物的 ED50 和 ED90 值分别为 0.2 和 1.3 mg/cm2。来自处理过的幼虫的薄片表现出 C. 通过前肠立方和中肠柱状细胞的空泡化，colocynthis 果实提取物在肠上皮细胞层上。该研究表明，C. colocynthis 的果实提取物具有显着的杀幼虫和驱虫活性，可用作控制疟疾媒介蚊子的理想方法。