Abstract A large number of pesticides used in agricultural practice has been characterized or suspected to be Endocrine Disruptors, with dietary intake to be the major route of consumer’s exposure. In the present study the safety to consumer after the consumption of pome fruits and fruiting vegetables originated from the area of Thessaly, Central Greece was assessed. Objective samplings of 110 samples were conducted in local retail markets in an effort to quantify potential residues of targeted pesticides, previously characterized as endocrine disruptors. For the determination of residues, a QuEChERs-based multiresidue method coupled with liquid and gas chromatographic systems was applied and fully validated in accordance with the European Unions’s requirements in apples and tomatoes in three fortification levels. Acceptable results were obtained for all the validation parameters studied and the limit of quantification of 0.01 mg/kg and limit of detection of 0.0033 mg/kg were achieved. Based on the determined results, the most frequently determined pesticide was chlorpyrifos with a maximum concentration of 0.32 mg/kg in tomato samples. Cypermethrin and dimethoate were also determined in tomatoes and aubergines. The EFSA PRIMo rev.3.1 model was applied for all positive samples and acute risk for consumers was confirmed only in the case of determination of chlorpyrifos in tomatoes.

中文翻译：

---

监测内分泌干扰物农药残留后的消费者安全评估：以希腊中部色萨利为例

摘要 农业实践中使用的大量农药已被鉴定或怀疑是内分泌干扰物，膳食摄入是消费者接触的主要途径。在本研究中，评估了食用源自希腊中部色萨利地区的梨果和果蔬对消费者的安全性。在当地零售市场对 110 个样本进行了客观抽样，以量化目标农药的潜在残留物，这些农药以前被定性为内分泌干扰物。对于残留量的测定，应用基于 QuEChERs 的多残留方法与液相和气相色谱系统相结合，并根据欧盟对苹果和西红柿三个强化级别的要求进行了充分验证。所研究的所有验证参数都获得了可接受的结果，并且达到了 0.01 mg/kg 的定量限和 0.0033 mg/kg 的检测限。根据测定结果，最常测定的农药是毒死蜱，番茄样品中的最大浓度为 0.32 mg/kg。还在西红柿和茄子中测定了氯氰菊酯和乐果。EFSA PRIMo rev.3.1 模型适用于所有阳性样本，仅在确定西红柿中的毒死蜱的情况下才确认消费者面临急性风险。番茄样品中为 32 mg/kg。还在西红柿和茄子中测定了氯氰菊酯和乐果。EFSA PRIMo rev.3.1 模型适用于所有阳性样本，仅在确定西红柿中的毒死蜱的情况下才确认消费者面临急性风险。番茄样品中为 32 mg/kg。还在西红柿和茄子中测定了氯氰菊酯和乐果。EFSA PRIMo rev.3.1 模型适用于所有阳性样本，仅在确定西红柿中的毒死蜱的情况下才确认消费者面临急性风险。