Abstract The purpose of this study was to investigate the protective effects of zinc nanoparticles against cisplatin-induced testicular toxicity in mice. Zinc nanoparticles were produced by microwave-assisted synthesis using Lavandula vera extract as reducing agent. Single doses of cisplatin (7 mg/kg, intraperitoneally) and ZnSO4 (10 mg/kg, orally), and various doses of zinc nanoparticles (10 − 50 mg/kg, orally) and vitamin E (100 mg/kg, interaperitoneally) were administered. The protective role of zinc nanoparticles was determined biochemically and histologically. Gradual reduction in malondialdehyde levels and elevation in glutathione levels and in the activities of superoxide dismutase and catalase upon administration of zinc nanoparticles were observed. The pathology of mice treated with cisplatin/vitamin E and cisplatin/zinc nanoparticles were apparently equal, but vitamin E treatment was more effective in lowering oxidative stress markers than zinc nanoparticles. These findings suggest that co-administration of zinc nanoparticles with cisplatin could prevent adverse effects on the male reproductive system via their potential antioxidant properties.

中文翻译：

---

微波辅助合成的锌纳米颗粒减轻顺铂诱导的小鼠睾丸毒性

摘要 本研究的目的是研究锌纳米颗粒对顺铂诱导的小鼠睾丸毒性的保护作用。使用薰衣草提取物作为还原剂，通过微波辅助合成制备锌纳米颗粒。单剂量顺铂（7 mg/kg，腹腔注射）和 ZnSO4（10 mg/kg，口服），以及不同剂量的锌纳米颗粒（10 - 50 mg/kg，口服）和维生素 E（100 mg/kg，腹腔注射）进行了管理。锌纳米颗粒的保护作用是通过生化和组织学确定的。观察到在施用锌纳米颗粒后丙二醛水平逐渐降低，谷胱甘肽水平升高以及超氧化物歧化酶和过氧化氢酶的活性逐渐升高。用顺铂/维生素 E 和顺铂/锌纳米颗粒治疗的小鼠的病理学明显相同，但维生素 E 治疗在降低氧化应激标志物方面比锌纳米颗粒更有效。这些发现表明，锌纳米颗粒与顺铂的共同给药可以通过其潜在的抗氧化特性来防止对男性生殖系统的不利影响。