ABSTRACT

The aim of the study was to evaluate the effect of Duvalia corderoyi (D. corderoyi) extracts in oxidative stress status and histopathology of liver and kidney tissues in streptozotocin (STZ)-induced diabetic rats. Fifty male Wistar albino rats were injected intraperitoneally (IP) with STZ. Rats with fasting blood glucose levels of 250 mg/dl and above were considered diabetic. Rats were subsequently fed orally with D. corderoyi extracts (100,200 mg/kg bw) for 30 days. Fasting blood glucose, insulin, and oxidative status in liver and kidney tissues were measured and histopathological analysis was performed. The blood glucose and malondialdehyde levels were decreased and the insulin, glutathione reductase, glutathione peroxidase, catalase, and superoxide dismutase levels were increased in D. corderoyi treated diabetic rats in comparison to those in untreated diabetic rats. Moreover, D. corderoyi relieved the injury in liver and kidney tissues of treated diabetic rats. Administration of D. corderoyi led to significant ameliorative effects on the oxidative stress and histopathology of liver and kidney tissues of D. corderoyi treated diabetic rats.

摘要

这项研究的目的是评估链球菌（STZ）诱导的糖尿病大鼠中杜氏提取物（D. corderoyi）提取物对氧化应激状态和肝肾组织病理学的影响。向五十只雄性Wistar白化病大鼠腹膜内（IP）注射STZ。空腹血糖水平为250 mg / dl及以上的大鼠被认为患有糖尿病。随后给大鼠口服D. corderoyi提取物（100,200 mg / kg bw）30天。测量肝和肾组织中的空腹血糖，胰岛素和氧化状态，并进行组织病理学分析。与未经治疗的糖尿病大鼠相比，经D. corderoyi治疗的糖尿病大鼠的血糖和丙二醛水平降低，胰岛素，谷胱甘肽还原酶，谷胱甘肽过氧化物酶，过氧化氢酶和超氧化物歧化酶水平升高。此外，D。corderoyi可以减轻糖尿病大鼠肝脏和肾脏组织的损伤。给予D. corderoyi导致对D. corderoyi治疗的糖尿病大鼠的氧化应激和肝肾组织的病理组织学有明显改善作用。