Selenium is a trace element which can be toxic when consumed at high levels. The study was conducted to assess the possible protective role of vitamin E against selenosis in rats. Selenium was applied at different single doses (4.5, 9 and 18 mg/kg b.wt.). Vitamin E (200 mg/kg b.wt.) was given to the rats one hour before treatment with the higher selenium dose. In selenium-treated rats, selenosis was evident from the elevated level of malondialdehyde. Oxidative stress was induced from the significant altered activity levels of CAT, SOD and GPx. Furthermore, selenium-induced hepatotoxicity was developed, where the activity levels of AST, ALT and GGT were significantly increased. Hepatotoxicity was also manifested histologically. Pretreatment with vitamin E significantly alleviated the affected levels of the investigated parameters, and counteracted the hepatic histopathological changes. The results demonstrate that vitamin E supplementation provides an effective protection against oxidative damage and hepatotoxicity induced by selenosis.

硒是微量元素，高水平摄入会产生毒性。进行该研究以评估维生素E对大鼠硒病的可能保护作用。硒以不同的单剂量（4.5、9和18 mg / kg b.wt.）施用。在用较高剂量的硒治疗前一小时，给大鼠服用了维生素E（200 mg / kg体重）。在用硒处理的大鼠中，丙二醛水平升高可明显引起硒病。CAT，SOD和GPx活性水平的显着改变引起了氧化应激。此外，开发了硒诱导的肝毒性，其中AST，ALT和GGT的活性水平显着增加。肝毒性在组织学上也有表现。维生素E预处理可大大减轻所研究参数的影响水平，并抵消了肝脏的组织病理学变化。结果表明，维生素E补充剂可有效抵抗由硒病引起的氧化损伤和肝毒性。