ABSTRACT

The present study examined the protective effects of curcuminoid isolates from Curcuma longa against carbon tetrachloride (CCL₄)-induced hepatic injury in rats. The hepatoprotective effect of the crude extract (150, 300 and 600 mg/kg bw) and curcuminoids (75, 150 and 300 mg bw) was evident by significant increases in the serum antioxidative defence capacities (super oxide dismutase, reduced glutathione, catalase) and reduction in biomarker enzymes of liver integrity (aspartate transaminase, alanine transaminase and alkaline phosphatase) in comparison to the results obtained in the CCL₄-untreated animals. Some of these parameters were completely restored by pre-treatments with curcuminoids. Similarly, the curcuminoids increases the concentrations of total proteins, albumins and ameliorated histological changes observed in CCL₄ injured rats. Therefore, curcuminoid could be considered a novel candidate for the development of new drug against liver diseases.

摘要

本研究检查了姜黄中的姜黄素类分离物对四氯化碳（CCL ₄）诱导的大鼠肝损伤的保护作用。血清抗氧化防御能力的显着提高（超氧化物歧化酶，还原型谷胱甘肽，过氧化氢酶）明显证明了粗提取物（150、300和600 mg / kg bw）和姜黄素（75、150和300 mg bw）的肝保护作用。与在CCL _4中获得的结果相比，肝脏完整性的生物标志物酶（天冬氨酸转氨酶，丙氨酸转氨酶和碱性磷酸酶）降低-未经处理的动物。通过使用姜黄素类药物进行预处理，这些参数中的一些已完全恢复。类似地，姜黄素类化合物增加了在CCL ₄损伤的大鼠中观察到的总蛋白，白蛋白的浓度和改善的组织学变化。因此，姜黄素可以被认为是开发抗肝病新药的新候选药物。