The antiplasmodial and safety profile of alkaloid, flavonoid and phenol extracts of Sida acuta (300 and 600 mg/kgbw) on hepatic and renal integrity of rats were investigated. Alkaloid, flavonoid and phenol extracts produce parasitaemia suppression of 50.83%, 33.50% and 64.64%, respectively. Sub-chronic administration of the phytochemicals caused marked (p < 0.05) dose-dependent increase in erythrocytic and leucocytic indices while serum ALP, AST, ALT, albumin, urea and creatinine concentrations compared well (p > 0.05) with the controls. Total proteins, sodium and chloride levels were altered in rats treated with 300 mg/kgbw of the phytochemicals. The integrity of hepatocytes and renal cells increases with increase extract concentrations and no degenerative changes were observed in all treatment groups. However, flavonoid extract caused severe renal vacuolation at 300 mg/kgbw which cleared out at 600 mg/kgbw. Conclusively, phenol exhibited higher antiplasmodial activities and safety profile and thus could be considered a potential candidate for the development of a new drug.

研究了a实生物碱，300和600 mg / kgbw的生物碱，类黄酮和苯酚提取物对大鼠肝脏和肾脏完整性的抗血浆和安全性。生物碱，类黄酮和苯酚提取物可分别抑制寄生虫血症50.83％，33.50％和64.64％。亚慢性施用植物化学物质导致红细胞和白细胞指数显着（p  <0.05）剂量依赖性增加，而血清ALP，AST，ALT，白蛋白，尿素和肌酐浓度比较好（p > 0.05）。用300 mg / kgbw的植物化学物质处理的大鼠的总蛋白质，钠和氯化物水平发生了变化。肝细胞和肾细胞的完整性随着提取物浓度的增加而增加，并且在所有治疗组中均未观察到变性的变化。然而，类黄酮提取物在300 mg / kgbw时引起严重的肾空泡，在600 mg / kgbw时清除。因此，苯酚具有较高的抗血浆活性和安全性，因此可以被认为是开发新药的潜在候选药物。