Abstract

Bacterial cellulose (BC) has been used in the combination with molecularly imprinted polymer (MIP) for controlled-release drug delivery. In the present study, the molecular imprinting was directly performed on BC to avoid the use of synthetic materials for sustained-release of quercetin, which was used as the template molecule. The phase inversion method was successfully used to prepare molecularly imprinted BC (MI-BC). The molecular recognition ability and controlled drug release behavior of MI-BC were then evaluated. MI-BC was found to have approximately 1.6 times higher ability to bind quercetin than the non-imprinted BC (NI-BC) did. The composite membrane containing MI-BC and quercetin (MI-BC-com) delayed and sustained drug release more effectively than the composite membrane containing NI-BC and quercetin (NI-BC-com). MI-BC-com released quercetin approximately two times more slowly than NI-BC-com did at the final hour of the drug release study. The mechanism of quercetin release followed the Higuchi model. Due to the relatively simple method of preparing the drug delivery system without using synthetic MIP, the application of MI-BC may be of great interest in medicine and pharmaceutics.

摘要

细菌纤维素 (BC) 已与分子印迹聚合物 (MIP) 结合用于控释药物递送。在本研究中，分子印迹直接在 BC 上进行，以避免使用合成材料来缓释作为模板分子的槲皮素。相转化方法成功地用于制备分子印迹BC（MI-BC）。然后评估了 MI-BC 的分子识别能力和药物控释行为。发现 MI-BC 结合槲皮素的能力比非印迹 BC (NI-BC) 高约 1.6 倍。含有MI-BC和槲皮素的复合膜(MI-BC-com)比含有NI-BC和槲皮素的复合膜(NI-BC-com)更有效地延迟和持续释放药物。在药物释放研究的最后一个小时，MI-BC-com 释放槲皮素的速度比 NI-BC-com 慢大约两倍。槲皮素的释放机制遵循樋口模型。由于制备给药系统的方法相对简单，无需使用合成 MIP，因此 MI-BC 的应用可能会在医学和制药领域受到极大的关注。