Abstract

A beneficial mircogel-reinforced polyvinyl alcohol (PVA) hydrogel is presented, aiming at improving its mechanical strength, self-healing, and drug-releasing features. The guar gum based microgel was prepared by inverse emulsion polymerization and cross-reacted with PVA and borax to form a network structure. The macro cross-linker and the PVA polymer chain were strongly bonded to generate a self-healable microgel-reinforced PVA hydrogel. The hydrogel was incorporated with hyaluronic acid and simulated its drug-releasing behavior. This work suggests that the microgel reinforced of macro-crosslinking PVA networks gives them a great potential in the design of self-healing and drug-releasing hydrogels.

摘要

提出了一种有益的微凝胶增强聚乙烯醇 (PVA) 水凝胶，旨在提高其机械强度、自愈性和药物释放特性。通过反相乳液聚合制备瓜尔胶基微凝胶，并与PVA和硼砂交叉反应形成网络结构。大交联剂和 PVA 聚合物链牢固结合，生成可自修复的微凝胶增强 PVA 水凝胶。水凝胶与透明质酸结合并模拟其药物释放行为。这项工作表明，大交联 PVA 网络增强的微凝胶在设计自愈和药物释放水凝胶方面具有巨大潜力。