Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma,International Journal of Polymeric Materials and Polymeric Biomaterials

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Celastrol-loaded liquid crystalline nanoparticles as an anti-inflammatory intervention for the treatment of asthma
International Journal of Polymeric Materials and Polymeric Biomaterials ( IF 2.5 ) Pub Date : 2020-05-31 , DOI: 10.1080/00914037.2020.1765350
Yinghan Chan ₁ , Sin Wi Ng ₁ , Dinesh Kumar Chellappan ₂ , Thiagarajan Madheswaran ₃ , Farrukh Zeeshan ₃ , Pradeep Kumar ₄ , Viness Pillay ₄ , Gaurav Gupta ₅ , Ridhima Wadhwa _{6,

7} , Meenu Mehta _{6,

7} , Peter Wark ₈ , Alan Hsu ₈ , Nicole G Hansbro _{6,

9} , Philip Michael Hansbro _{6,

8,

9} , Kamal Dua _{6,

7,

8} , Jithendra Panneerselvam ₃

Affiliation

School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia;
Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Kuala Lumpur, Malaysia;
Department of Pharmaceutical Technology, International Medical University (IMU), Kuala Lumpur, Malaysia;
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa;
School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India;
Centenary Institute, Royal Prince Alfred Hospital, Camperdown, Australia;
Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney (UTS), Ultimo, Australia;
Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI) and School of Biomedical Sciences and Pharmacy, The University of Newcastle (UoN), Callaghan, Australia;
School of Life Sciences, University of Technology Sydney (UTS), Ultimo, Australia

The present study aimed to formulate celastrol into liquid crystalline nanoparticles (LCNPs) through ultrasonication to enhance its therapeutic efficacy in the treatment of asthma. The physiochemic...

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