Abstract A biocompatible zinc (II) complex based on a tetradentate N,N,O,O-type salen ligand was synthesized, characterized and used for the solvent-free ring-opening polymerization (ROP) of L-lactide in bulk at 180 °C to prepare high molecular weight poly(L-lactide) (Mn : 82,600 Da; Mw : 140,000 Da; PDI: 1.70). Poly(L-lactide) (PLLA) was characterized using FTIR, 1H NMR, 13C NMR, GPC, TGA, DSC, WAXD, and MALDI-ToF. Kinetic measurement was carried out and first-order behavior to monomer was observed. The k app was found as 6 ± 0.001 × 10−4 s−1. The biocompatibility of the PLLA was confirmed by in vitro cytotoxicity against NIH/3T3 fibroblast cell line and can be used in biomedical applications.

中文翻译：

---

使用锌 (II) salen 复合物合成和表征生物相容性聚 (L-丙交酯)

摘要 合成、表征了一种基于四齿 N,N,O,O 型 salen 配体的生物相容性锌 (II) 配合物，并将其用于 L-丙交酯在 180° 下本体的无溶剂开环聚合 (ROP)。 C 制备高分子量聚（L-丙交酯）（Mn：82,600 Da；Mw：140,000 Da；PDI：1.70）。使用 FTIR、1H NMR、13C NMR、GPC、TGA、DSC、WAXD 和 MALDI-ToF 表征聚（L-丙交酯）（PLLA）。进行动力学测量并观察到单体的一级行为。发现 k app 为 6 ± 0.001 × 10−4 s−1。PLLA 的生物相容性通过对 NIH/3T3 成纤维细胞系的体外细胞毒性得到证实，可用于生物医学应用。