Abstract

A new zinc (II) coordination polymer (CP) with the chemical formula of [Zn₃(L)₂(mtba)₂]_n (1) (L = 1,4-bis(benzimidazol-1-yl)-2-butene, H₃mtb= 5-methoxybenzene-1,2,3-tricarboxylic acid) was hydrothermally synthesized by reaction of ZnSO₄ · 7H₂O with the 1,2,3-benzenetricarboxylic acid in the presence of the 1,4-bis(benzimidazol-1-yl)-2-butene ligand. Its anti-cancer activity on the lymphoma, bombinated with anthracyclines, doxorubicin was evaluated in this research. First, the cell apoptosis detection kit was used to detect the percentages of the apoptotic lymphoma cells after compound treatment. Next, the real-time RT-PCR was performed for the evaluation of the p53 and bcl-2 genes relative expression in the lymphoma cells. Results from molecular docking simulation have shown that the biological activity are directly related to the carbonyl functional group.

抽象的

化学式为[Zn ₃（L）₂（mtba）₂ ] _n（1）（L = 1,4-双（苯并咪唑-1-基）-2- ）的新型锌（II）配位聚合物（CP）ZnSO ₄  ·7H ₂反应水热合成H ₃ mtb = 5-甲氧基苯-1,2,3-三羧酸丁烯在1,4-双（苯并咪唑-1-基）-2-丁烯配体存在的情况下将O与1,2,3-苯三羧酸一起使用。在这项研究中评估了其对淋巴瘤的抗癌活性，所述淋巴瘤被蒽环类抗生素，阿霉素所轰击。首先，使用细胞凋亡检测试剂盒检测化合物处理后凋亡淋巴瘤细胞的百分比。接下来，进行实时RT-PCR以评估淋巴瘤细胞中p53和bcl-2基因的相对表达。分子对接模拟的结果表明，生物活性与羰基官能团直接相关。