Abstract

In the current study, two new Cu(II)-containing coordination polymers (CPs) with the chemical formula of {[Cu₂(Py₂TTz)(2-CH₃-BDC)₂]·2(DMF)·3(H₂O)}n (1, 2-CH₃-H₂BDC = 2-methyl-1,4-benzenedicarboxylic acid) and {[Cu₂(Py₂TTz)₂(1,3-BDC)₂]·3(DMF)·3(H₂O)}_n (2, 1,3-H₂BDC = 1,3-benzenedicarboxylic acid) has been successfully prepared by reaction of Cu(NO₃)₂·3H₂O with the rigid 2,5-bis(4-pyridyl)thiazolo[5,4-d]thiazole (Py₂TTz) in the presence of different dicarboxylic acid ligands. Their treatment activity on the neonatal septic infections was evaluated and the specific mechanism was also explored. The percentage of the apoptotic lymphocytes during neonatal septic infections was measured with FITC/PI staining assay after compounds treatment. In addition to this, after indicated treatment, the serum procalcitonin (PCT) content during sepsis was further detected with the ELISA detection kit.

摘要

在当前的研究中，两种新的化学式为{[Cu ₂（Py ₂ TTz）（2-CH ₃ -BDC）₂ ]·2（DMF）·3（ ħ ₂ O）} N（1，2-CH ₃ -H ₂ BDC = 2-甲基-1,4-苯二羧酸）和{[铜₂（PY ₂ TTZ）₂（1,3-BDC）₂ ]· 3（DMF）·3（H ₂ O）} _ñ（2，1,3--H ₂ BDC = -1,3-苯二甲酸）已成功地用Cu的反应制备（NO ₃）₂ ·3H ₂在不同的二羧酸配体存在下，使用带有刚性2,5-双（4-吡啶基）噻唑并[5,4- d ]噻唑（Py ₂ TTz）的O。评价了它们对新生儿败血症感染的治疗活性，并探讨了其具体机制。化合物处理后，通过FITC / PI染色法测定新生儿败血症感染期间凋亡淋巴细胞的百分比。除此之外，在指定的治疗后，使用ELISA检测试剂盒进一步检测败血症期间的血清降钙素（PCT）含量。