Abstract

Two new heterometallic coordination polymers (CPs) formulated as [LaCoCl(2,5-pydc)₂(H₂O)₄]Cl (1, 2,5-H₂pydc = pyridine-2,5-dicarboxylic acid) and [LaCoCl₂(5,5 = pyridin₃)(H₂O)] (2, 5,5′-H₂bpdc = 2,2ridine-2,5-dicar-dicarboxylic acid) have been solvothermally synthesized on the basis of the coordination between rare earth/transition metal ions and pyridinedicarboxylic acids. Their treatment activity on diabetic foot (DF) was evaluated in biological research. First of all, the content of the inflammatory cytokines in the plantar tissue was measured with the ELISA detection kit. Next, the real-time RT-PCR was performed for the measurement of the TLR-4–NF-κB signaling pathway activation.

摘要

配制成两个新的杂金属配位聚合物（CPS）[LaCoCl（2,5- pydc）₂（H ₂ O）₄ ] Cl（上1，2,5--H ₂ pydc =吡啶-2,5-二羧酸）和[ LaCoCl ₂（5,5 =吡啶₃）（H ₂ O）]（2，5,5'--H ₂在稀土/过渡金属离子与吡啶二羧酸之间的配位基础上，溶剂热合成了bpdc = 2,2ridine-2,5-二甲基二羧酸。在生物学研究中评估了它们对糖尿病足（DF）的治疗活性。首先，用ELISA检测试剂盒测量足底组织中炎性细胞因子的含量。接下来，进行实时RT-PCR测量TLR-4–NF-κB信号通路的激活。