Abstract

By using a mixed-ligand approach, two new coordination polymers with the chemical formula of {[Zn(L)(ip)·H₂O]₈}_n (1, H₂ip = isophthalic acid and L = 1,1’-(2-methylpropane-1,3-diyl)bis(1H-benzo[d]imidazole)) and {[Ni(L)(tdc)·2H₂O]₂}_n (2, H₂tdc = 2,5-thiophenedicarboxylic acid) have been hydrothermally synthesized and structurally characterized by single-crystal X-ray diffraction analyses, powder X-ray diffraction, thermogravimetric analysis and elemental analysis. In addition, in vitro anticancer activity of compounds 1 and 2 on four human ovarian cancer cells (CoC1, A2780, 3AO and OVCAR) was further determined. The results showed that compared with their organic ligands, the two compounds displayed efficient antitumor activity.

通过使用混合配体方法，化学式为{[Zn（L）（ip）·H ₂ O] ₈ } _n（1，H ₂ ip =间苯二甲酸，L = 1,1' -（2-甲基丙烷-1,3-二基）双（1H-苯并[d]咪唑））和{[Ni（L）（tdc）·2H ₂ O] ₂ } _n（2，H ₂ tdc = 2，已经通过水热合成并通过单晶X射线衍射分析，粉末X射线衍射，热重分析和元素分析对其结构进行了表征。此外，在体外的化合物的抗癌活性1和2进一步确定在四个人卵巢癌细胞（COC1，A2780，3AO和OVCAR）。结果表明，与它们的有机配体相比，这两种化合物均显示出有效的抗肿瘤活性。