Abstract

New mononuclear copper(II), nickel(II) and cobalt(II) hydrazone complexes of 2-cyano-N′-((4-oxo-4H-chromen-3-yl)methylene)acetohydrazide have been synthesized. Structure identification of the prepared complexes was carried out by physicochemical and spectroscopic techniques including elemental analyses, infrared, electronic, mass and electron spin resonance spectra, thermal analysis, conductivity and magnetic susceptibility measurements, powder x-ray diffraction and transmission electron microscope. The isolated binary complexes are neutral mononuclear complexes (with 1:1 and 1:2; M:L stoichiometries) and ternary complexes (with 1:1:1; M:L:L′ stoichiometry). The analytical and spectroscopic techniques illustrated the monoanionic tridentate behavior of the hydrazone ligand with γ-pyrone oxygen, enolic oxygen and azomethine nitrogen coordinating sites. The metal complexes displayed square planar, tetrahedral and octahedral geometries. Density Functional Theory calculations were carried out for the chelating agent and its copper(II) chelates. The phenoxazinone synthase activity of the binary copper(II) complexes was studied and discussed. The antimicrobial activity of the hydrazone ligand and its complexes was evaluated toward some sorts of Gram–positive bacteria, Gram–negative bacteria, yeast and fungus.

合成了2-氰基-N'-（（4-氧代-4H-铬-3-基）亚甲基）乙酰肼的新型单核铜（II），镍（II）和钴（II）配合物。通过物理化学和光谱技术对制备的配合物进行结构鉴定，包括元素分析，红外，电子，质量和电子自旋共振光谱，热分析，电导率和磁化率测量，粉末X射线衍射和透射电子显微镜。分离的二元络合物是中性单核络合物（具有1：1和1：2； M：L化学计量比）和三元络合物（具有1：1：1； M：L：L'化学计量比）。分析和光谱技术说明了ligand配体与γ-吡喃酮氧的单阴离子三齿行为，烯醇氧和甲亚胺氮的配位位点。金属络合物显示方形平面，四面体和八面体几何形状。对螯合剂及其铜（II）螯合物进行了密度泛函理论计算。研究和讨论了二元铜（II）配合物的苯恶嗪酮合酶活性。评估了ligand配体及其配合物对某些革兰氏阳性菌，革兰氏阴性菌，酵母菌和真菌的抗菌活性。