Bone-graft material consisting of 200 ~ 1500 micrometre-sized granular powder has recently been used. However, it is difficult to place granular powder in the defective area of a bone, and this can result in the loss of bone-graft material during surgery. On the other hand, nano-sized bone-graft powder exhibits superior graft efficiency. Thus, we proposed the manufacture of moldable block-type bone-graft materials from nano-sized hydroxyapatite(HAp)-sol and methylcellulose (MC), which is widely used as a thickener. Composites of various HAp-sol and MC concentrations were fabricated and their viscosity was measured. The composites were freeze-dried to fabricate blocks, and their microstructure was studied. pH and cell viability tests were conducted to verify that the biological stability of the bone-grafting materials was not impaired by the MC. A tooth-injection test was conducted in a simulated body fluid (SBF) solution over three months; this demonstrated that the composite bone-graft materials were activated in the SBF solution.

中文翻译：

---

用于骨移植的甲基纤维素/羟基磷灰石复合材料

最近使用了由 200 ~ 1500 微米大小的颗粒粉末组成的骨移植材料。然而，很难将颗粒状粉末放置在骨骼的缺损区域，这可能会导致手术过程中骨移植材料的损失。另一方面，纳米尺寸的骨移植粉表现出优异的移植效率。因此，我们建议从纳米羟基磷灰石 (HAp)-溶胶和甲基纤维素 (MC) 制造可模压的块状骨移植材料，甲基纤维素 (MC) 被广泛用作增稠剂。制备了各种 HAp-sol 和 MC 浓度的复合材料，并测量了它们的粘度。将复合材料冷冻干燥制成块体，并对其微观结构进行了研究。进行 pH 值和细胞活力测试以验证骨移植材料的生物稳定性不受 MC 影响。在模拟体液 (SBF) 溶液中进行了三个月的牙齿注射测试；这表明复合骨移植材料在 SBF 溶液中被激活。