Monofluorinated Nitrogen Containing Heterocycles: Synthesis, Characterization and Fluorine Effect,Zeitschrift für anorganische und allgemeine Chemie

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Monofluorinated Nitrogen Containing Heterocycles: Synthesis, Characterization and Fluorine Effect
Zeitschrift für anorganische und allgemeine Chemie ( IF 1.1 ) Pub Date : 2020-07-29 , DOI: 10.1002/zaac.202000239
Marco Reichel ₁ , Konstantin Karaghiosoff ₁

Affiliation

A straight forward synthesis and efficient introduction of fluoromethyl group in nitrogen heterocycles is reported. Starting from the respective NH heterocycles fluoromethylation is performed with fluoroiodomethane and proceeds under mild reaction conditions. Structural information of monofluoromethylated nitrogen‐containing cyclic compounds containing the biologically active NCH2F moiety are reported. The particularly impressively change of physical and spectroscopic properties by the substitution of a methyl group by a monofluoromethyl group is discussed based on these examples.

中文翻译：

含单氟化氮的杂环：合成、表征和氟效应

报道了在氮杂环中直接合成和有效引入氟甲基。从各自的 NH 杂环开始，氟甲基化是用氟碘甲烷进行的，并在温和的反应条件下进行。报告了含有生物活性 NCH2F 部分的单氟甲基化含氮环状化合物的结构信息。基于这些实施例讨论了由单氟甲基取代甲基所引起的物理和光谱性质的特别令人印象深刻的变化。

更新日期：2020-07-29

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