Fluorescent cyclic peptides for cell imaging,Peptide Science

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Fluorescent cyclic peptides for cell imaging
Peptide Science ( IF 1.5 ) Pub Date : 2020-07-02 , DOI: 10.1002/pep2.24181
Lorena Mendive‐Tapia ₁ , Jinling Wang ₁ , Marc Vendrell ₁

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Fluorescent cyclic peptides are excellent chemical scaffolds to build optical agents for molecular imaging. In addition to their favorable physicochemical properties, they can be modified with multiple organic fluorophores and generate useful probes for biological assays targeting specific proteins, namely receptors or enzymes. In this article, we review recent advances in the synthetic approaches for the preparation of fluorescent cyclic peptides as well as some of their applications in biological imaging, from in vitro live‐cell imaging studies to in vivo characterization of preclinical models.

中文翻译：

用于细胞成像的荧光环肽

荧光环肽是出色的化学支架，可构建用于分子成像的光学试剂。除了具有良好的理化特性外，还可以使用多种有机荧光团对其进行修饰，并生成有用的探针，用于针对特定蛋白质（即受体或酶）的生物学检测。在本文中，我们回顾了制备荧光环状肽的合成方法的最新进展及其在生物成像中的一些应用，从体外活细胞成像研究到临床前模型的体内表征。

更新日期：2020-07-02

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