In this work, we studied and discussed a relevant aspect of peptide science, strictly related to the scientific production of Prof. Louis A. Carpino who passed away in early 2019. Specifically, we carried out a statistical survey on the significant 3D‐structural parameters (bond lengths, bond angles, and torsion angles) of the currently extensively used 9‐fluorenylmethyloxycarbonyl (Fmoc) α‐amino protecting group introduced by Carpino in peptide synthesis. In this compilation, we considered all 131 X‐ray diffraction structures available in the literature on amino acid / linear peptide derivatives and Fmoc‐labeled amines. Both Fmoc secondary and tertiary urethane functionalities were examined and separately analyzed.

中文翻译：

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从阿默斯特（美国马萨诸塞州）到帕多瓦（意大利），再返回：路易·卡皮诺的科学生产之旅

在这项工作中，我们研究和讨论了与肽科学有关的方面，该方面与2019年初去世的Louis A.Carpino教授的科学成果紧密相关。具体地说，我们对重要的3D结构参数进行了统计调查Carpino在肽合成中引入的目前广泛使用的9-芴基甲氧羰基（Fmoc）α-氨基保护基的键长度，键角和扭转角）。在本汇编中，我们考虑了文献中有关氨基酸/线性肽衍生物和Fmoc标记的胺的所有131个X射线衍射结构。Fmoc的第二级和第三级氨基甲酸酯官能度均经过检查并分别进行了分析。