Impact of age-, cancer-, and treatment-driven inflammation on T cell function and immunotherapy.,Journal of Leukocyte Biology

当前位置： X-MOL 学术 › J. Leukoc. Biol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Impact of age-, cancer-, and treatment-driven inflammation on T cell function and immunotherapy.
Journal of Leukocyte Biology ( IF 3.6 ) Pub Date : 2020-07-17 , DOI: 10.1002/jlb.5mr0520-466r
Kylie M Quinn _{1,

2} , Apriliana E R Kartikasari ₁ , Rachel E Cooke _{3,

4} , Rachel M Koldej _{3,

4} , David S Ritchie _{3,

4} , Magdalena Plebanski ₁

Affiliation

Many cancers are predominantly diagnosed in older individuals and chronic inflammation has a major impact on the overall health and immune function of older cancer patients. Chronic inflammation is a feature of aging, it can accelerate disease in many cancers and it is often exacerbated during conventional treatments for cancer. This review will provide an overview of the factors that lead to increased inflammation in older individuals and/or individuals with cancer, as well as those that result from conventional treatments for cancer, using ovarian cancer (OC) and multiple myeloma (MM) as key examples. We will also consider the impact of chronic inflammation on immune function, with a particular focus on T cells as they are key targets for novel cancer immunotherapies. Overall, this review aims to highlight specific pathways for potential interventions that may be able to mitigate the impact of chronic inflammation in older cancer patients.

中文翻译：

年龄，癌症和治疗驱动的炎症对T细胞功能和免疫疗法的影响。

许多癌症主要在老年患者中诊断出来，慢性炎症对老年癌症患者的整体健康和免疫功能产生重大影响。慢性炎症是衰老的特征，它可以加速许多癌症的疾病，并且在传统的癌症治疗方法中通常会加剧。这篇综述将概述以卵巢癌（OC）和多发性骨髓瘤（MM）为关键的导致老年人和/或患有癌症的个体炎症增加的因素，以及由常规癌症治疗导致的炎症因素例子。我们还将考虑慢性炎症对免疫功能的影响，特别关注T细胞，因为它们是新型癌症免疫疗法的关键靶标。总体，

更新日期：2020-08-27

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11