Phenotypically defined subpopulations of circulating follicular helper T cells in common variable immunodeficiency.,Immunity, Inflammation and Disease

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Phenotypically defined subpopulations of circulating follicular helper T cells in common variable immunodeficiency.
Immunity, Inflammation and Disease ( IF 3.1 ) Pub Date : 2020-07-02 , DOI: 10.1002/iid3.326
Sait Yesillik ₁ , Sudhir Gupta ₁

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Common variable immunodeficiency (CVID) is characterized by low immunoglobulin G and IgA/IgM, decreased switched memory B cells, impaired response to vaccine, and an increased susceptibility to infections and autoimmunity. T_FH cells play an important role in germinal center reaction where it supports isotype switching, somatic hypermutation, generation of memory B cells, and differentiation of B cells to plasma cells. The objective was to study the distribution of three subsets of T_FH cells and their relationship with autoimmune diseases associated with CVID.

中文翻译：

常见变异性免疫缺陷中循环滤泡辅助 T 细胞的表型定义亚群。

常见变异型免疫缺陷 (CVID) 的特点是免疫球蛋白 G 和 IgA/IgM 低、转换记忆 B 细胞减少、对疫苗的反应受损以及对感染和自身免疫的易感性增加。 T _FH细胞在生发中心反应中发挥重要作用，支持同种型转换、体细胞超突变、记忆 B 细胞的生成以及 B 细胞向浆细胞的分化。目的是研究 T _FH细胞的三个亚群的分布及其与 CVID 相关自身免疫性疾病的关系。

更新日期：2020-08-10

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