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Relationship between the Young's Modulus and the Crystallinity of Cross-Linked Poly(ε-caprolactone) as an Immobilization Membrane for Cancer Radiotherapy.
Global Challenges ( IF 4.4 ) Pub Date : 2020-06-17 , DOI: 10.1002/gch2.202000008
Jie Dong 1 , Jinchao Liu 2 , Xing Li 3 , Qingyou Liang 2 , Xiangying Xu 1
Affiliation  

Cancer is a leading cause of death in the world. In cancer radiotherapy, immobilization membranes composed of cross‐linked poly(ε‐caprolactone) (PCL) are utilized for patient positioning. A higher‐dimensional stability of the membrane is urgently required to facilitate more accurate radiation dose delivery. It is extremely important to establish the relationship between the degree of crystallinity and the Young's modulus (E) because it determines the mechanical properties and can be modulated by crystallinity. When two components of the membrane with different strains are in contact, a gradient region adjacent to the interface is formed and confirmed by attenuated total reflection infrared microscopy. Atomic force microscopy (AFM) and Raman spectroscopy are used to scan the same area in the gradient region (14 µm × 14 µm) to characterize E and crystallinity (XRaman), respectively. This co‐localized method ensures the accuracy of the relationship. Finally, 1764 AFM measurement data are processed and 49 pairs of EXRaman data are obtained. The regression curve shows that E monotonically increases with XRaman. The nonlinearity of the curve may be attributed to the α‐relaxation and cross‐linking of PCL chains. The chemical structure of this material significantly impacts the mechanical properties, thus requiring future investigation.

中文翻译:


交联聚(ε-己内酯)作为癌症放射治疗固定膜的杨氏模量与结晶度之间的关系。



癌症是世界上主要的死亡原因。在癌症放射治疗中,由交联聚(ε-己内酯)(PCL)组成的固定膜用于患者定位。迫切需要膜具有更高的尺寸稳定性,以促进更准确的辐射剂量输送。建立结晶度和杨氏模量 ( E ) 之间的关系极其重要,因为它决定机械性能并且可以通过结晶度进行调节。当具有不同应变的膜的两个组件接触时,会形成邻近界面的梯度区域,并通过衰减全反射红外显微镜证实。使用原子力显微镜 (AFM) 和拉曼光谱扫描梯度区域 (14 µm × 14 µm) 中的同一区域,分别表征E和结晶度 ( X拉曼)。这种共定位方法确保了关系的准确性。最终对1764个AFM测量数据进行处理,得到49对E - X拉曼数据。回归曲线显示EX拉曼单调增加。曲线的非线性可能归因于 PCL 链的 α 弛豫和交联。这种材料的化学结构显着影响机械性能,因此需要进一步的研究。
更新日期:2020-06-17
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