Colorectal cancer, common in both men and women, occurs when tumors form in the linings of the colon. Common treatments of colorectal cancer include surgery, chemotherapy, and radiation therapy; however, many colorectal cancer treatments often damage healthy tissues and cells, inducing severe side effects. Conventional chemotherapeutic agents such as doxorubicin (Dox) can be potentially used for the treatment of colorectal cancer; however, they suffer from limited targeting and lack of selectivity. Here, we report that doxorubicin complexed to hyaluronic acid (HA) (HA‐Dox) exhibits an unusual behavior of high accumulation in the intestines for at least 24 hr when injected intravenously. Intravenous administrations of HA‐Dox effectively preserved the mucosal epithelial intestinal integrity in a chemical induced colon cancer model in mice. Moreover, treatment with HA‐Dox decreased the expression of intestinal apoptotic and inflammatory markers. The results suggest that HA‐Dox could effectively inhibit the development of colorectal cancer in a safe manner, which potentially be used a promising therapeutic option.

中文翻译：

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透明质酸-阿霉素纳米颗粒用于结直肠癌的靶向治疗

结直肠癌在男性和女性中都很常见，当结肠内壁形成肿瘤时就会发生结直肠癌。结直肠癌的常见治疗方法包括手术、化疗和放射治疗；然而，许多结直肠癌治疗方法常常会损害健康的组织和细胞，从而引发严重的副作用。传统化疗药物如阿霉素（Dox）可潜在用于治疗结直肠癌；然而，它们的目标有限且缺乏选择性。在这里，我们报告，静脉注射时，与透明质酸 (HA) 复合的阿霉素 (HA-Dox) 表现出一种不寻常的行为，即在肠道中高积累至少 24 小时。在化学诱导的小鼠结肠癌模型中，静脉注射 HA-Dox 可有效保留粘膜上皮肠的完整性。此外，HA-Dox 治疗降低了肠道凋亡和炎症标志物的表达。结果表明，HA-Dox 可以以安全的方式有效抑制结直肠癌的发展，这可能成为一种有前景的治疗选择。