Abstract This works presented the surface modification of magnetite nanoparticles (MNPs) with the copolymers containing hydrophilic mPEG and hydrophobic polyester for use in drug controlled release applications. Polyester moieties in the copolymers were adsorbed on MNPs to form hydrophobic layer for entrapment of a hydrophobic indomethacin model drug, while hydrophilic mPEG provided their good water dispersibity. Three different polyester structures in the copolymer for MNP coating were; 1) saturated, 2) unsaturated and 3) crosslinked polyesters. The copolymer structures were characterized via 1H NMR and their coatings were confirmed by FTIR. These water dispersible MNPs contained 53–61% copolymer in the complexes with the size ranging between 8 and 14 nm. The MNPs containing saturated polyester showed higher drug entrapment and loading efficiencies than the other two samples. Interestingly, those containing crosslinked polyester exhibited a potential to sustain the release of the entrapped drug. These complexes might be suitable for use as vehicles for entrapment of hydrophobic drugs with tunable and controllable release rate.

中文翻译：

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磁铁矿纳米颗粒包覆的两亲共聚物聚酯结构设计：对吲哚美辛负载和缓释的影响

摘要 这项工作介绍了磁铁矿纳米粒子 (MNP) 的表面改性，其中包含亲水性 mPEG 和疏水性聚酯的共聚物，用于药物控释应用。共聚物中的聚酯部分被吸附在 MNPs 上形成疏水层，用于包埋疏水性吲哚美辛模型药物，而亲水性 mPEG 提供了良好的水分散性。用于 MNP 涂层的共聚物中的三种不同聚酯结构是：1) 饱和的，2) 不饱和的和 3) 交联的聚酯。共聚物结构通过 1 H NMR 表征，其涂层通过 FTIR 确认。这些水分散性 MNP 在配合物中含有 53-61% 的共聚物，尺寸范围在 8 到 14 nm 之间。与其他两个样品相比，含有饱和聚酯的 MNP 显示出更高的药物包封率和负载效率。有趣的是，含有交联聚酯的那些表现出持续释放被包裹药物的潜力。这些复合物可能适合用作载体，用于以可调和可控的释放速率包埋疏水性药物。