Abstract Conceptualizing surfactant vesicles as soft templates to construct nanometer sized hollow inorganic spheres require understanding the interactions between vesicle bilayers and growing material. Herein we had investigated the spontaneous vesicle formation in an aqueous catanionic system, composed of strategically designed cationic ester functionalized morpholinium based surfactant, 4-methyl-4-(2-(octyloxy)-2-oxoethyl)morpholine-4-ium bromide [C8EMorph][Br] and conventional anionic surfactant, sodium dodecyl sulfate. These catanionic vesicles were characterized using state of the art analytical techniques including small angle neutron scattering (SANS) and then used as the soft templates to synthesize hollow silica-nanospheres (HSNS) with size ranging from 45 to 85 nm and pore volume of 0.989 cm3•g−1. The HSNS thus prepared were used to encapsulate an anti-inflammatory drug, diclofenac sodium. The subtle combination of the hollow interior with the mesoporous shells of the HSNS circumvent the limitations of traditional drug delivery system and could open new promising prospects in various fields including biomedical one.

中文翻译：

---

基于功能化表面活性剂的阳离子囊泡作为软模板合成空心二氧化硅纳米球作为新时代的药物载体

摘要 将表面活性剂囊泡概念化为构建纳米级空心无机球体的软模板需要了解囊泡双层和生长材料之间的相互作用。在此，我们研究了水性阳离子体系中的自发囊泡形成，该体系由战略性设计的阳离子酯官能化吗啉基表面活性剂、4-甲基-4-(2-(辛氧基)-2-氧乙基)吗啉-4-溴化物 [C8EMorph ][Br] 和传统的阴离子表面活性剂，十二烷基硫酸钠。这些阳离子囊泡使用最先进的分析技术进行表征，包括小角中子散射 (SANS)，然后用作软模板合成尺寸范围为 45 至 85 nm 和孔体积为 0.989 cm3 的空心二氧化硅纳米球 (HSNS) •g-1。如此制备的HSNS用于封装抗炎药双氯芬酸钠。HSNS 的中空内部与介孔壳的巧妙结合规避了传统药物递送系统的局限性，可以在包括生物医学领域在内的各个领域开辟新的前景。