The ability of an individual to reduce the intensity, duration or frequency of a stressor is a critical determinant of the consequences of that stressor on physiology and behavior. To expand our understanding of the brain networks engaged during controllable and uncontrollable stress and to identify sex differences, we used functional connectivity analyses of the immediate early gene product Fos in male and female rats exposed to either controllable or uncontrollable tail shocks. Twenty-eight regions of interest (ROI) were selected from the structures previously evinced to be responsible for stress response, action-outcome learning, or sexual dimorphism. We found that connectivity across these structures was strongest in female rats without control while weaker connectivity was evident in male rats with control over stress. Interestingly, this pattern correlates with known behavioral sex differences where stressor controllability leads to resilience in male but not female rats. Graph theoretical analysis identified several structures important to networks under specific conditions. In sum, the findings suggest that control over stress reshapes functional connectivity.

个人降低压力源的强度，持续时间或频率的能力是该压力源对生理和行为后果的关键决定因素。为了扩大我们对可控和不可控压力下参与的大脑网络的了解并确定性别差异，我们对暴露于可控或不可控尾巴电击的雄性和雌性大鼠的早期早期基因产物Fos进行了功能连通性分析。从先前证明负责压力​​反应，行动成果学习或性二态性的结构中选择了二十八个兴趣区域（ROI）。我们发现，在没有控制的雌性大鼠中，跨这些结构的连接性最强，而在控制压力的雄性大鼠中，连接性较弱。有趣的是 这种模式与已知的行为性别差异有关，其中应激源的可控性导致雄性大鼠而非雌性大鼠产生弹性。图理论分析确定了在特定条件下对网络重要的几种结构。总而言之，研究结果表明，对压力的控制重塑了功能连通性。