Abstract Hydroxyapatite nanoparticles are utilized extensively in the era of nanotechnology to deliver various drugs to the right area. However, the molecular mechanism behind the transportation of these nanoparticles and its effect on the development and maintenance of sensory organs is not known. The current study aims to check the effect of hydroxyapatite nanoparticle (HApNP) on sensory organs of Drosophila. Various concentrations of HApNP (10 mg·L−1, 20 mg·L−1, 40 mg·L−1 and 80 mg·L−1) were mixed with fly food and the developmental defects were monitored. Sensory organs like the eye and the mechanosensory organs were studied in a developmental time window. The larval eye-antennae and wing imaginal discs were checked for apoptotic cell death. In pupae, the damage becomes more prominent and it persists till adult. In the adult fly, the eye with a fused facet, defective cone and rhabdomere appear. Similarly, the wing with wing spots, macrochaetae, and defective alignment of hairs were also observed. All these phenotypic defects suggest the mistargeting of various proteins involved in the development. The current study correlates the phenotypic defects observed in the eye and wing is due to the down-regulation of the genes associated with the retromer complex.

中文翻译：

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羟基磷灰石纳米颗粒通过靶向黑腹果蝇的逆向复合物引起感觉器官缺陷

摘要 在纳米技术时代，羟基磷灰石纳米颗粒被广泛用于将各种药物输送到正确的区域。然而，这些纳米颗粒运输背后的分子机制及其对感觉器官发育和维持的影响尚不清楚。目前的研究旨在检查羟基磷灰石纳米颗粒 (HApNP) 对果蝇感觉器官的影响。将不同浓度的 HApNP（10 mg·L-1、20 mg·L-1、40 mg·L-1 和 80 mg·L-1）与苍蝇食物混合并监测发育缺陷。在发育时间窗口中研究了像眼睛和机械感觉器官这样的感觉器官。检查幼虫眼触角和翼成虫盘的凋亡细胞死亡。在蛹中，损害变得更加突出，并持续到成虫。在成年苍蝇中，出现带有融合面、有缺陷的锥体和横纹球的眼睛。类似地，还观察到带有翼斑、巨毛纲和毛发排列缺陷的翅膀。所有这些表型缺陷表明参与发育的各种蛋白质的靶向错误。目前的研究将眼睛和翅膀中观察到的表型缺陷相关联，这是由于与逆转录复合体相关的基因下调。