Surface-Enhanced Raman Spectroscopy attracts great interests for its ability to detect a variety of molecules at trace level. However, the commonly used noble metal substrates suffer from high cost, poor biocompatibility and inferior stability. Some oxides have the potential to substitute for noble metal and much effort has been made to improve their performance. In this paper, MoO₂ nanocones were prepared and self-assembled into hollow spheres. The structure exhibits an enhancement factor (EF) of 3 × 10⁷ and a limit of detection (LOD) of 10⁻⁹ M for Rhodamine 6G (R6G). This performance is among the best of all the oxides and is comparable to that of Au and Ag. The morphology control of hollow MoO₂ sphere was also discussed.

表面增强拉曼光谱技术以痕量水平检测各种分子的能力引起了人们的极大兴趣。但是，通常使用的贵金属基材成本高，生物相容性差，稳定性差。一些氧化物有可能替代贵金属，并且已经进行了很多努力来改善其性能。本文制备了MoO ₂纳米锥并自组装成空心球。该结构显示出的3×10的增强因子（EF）⁷的10和检测（LOD）的限制^-9  M表示罗丹明6G（R6G）。该性能是所有氧化物中最好的，可与Au和Ag媲美。还讨论了空心MoO ₂球的形貌控制。