The presence of certain pharmaceutical compounds in ground and surface waters may constitute a serious environmental problem, even at low concentrations. The removal of these compounds is a trending research topic that implies a wide variety of disciplines. To provide clear insight into this field of research, a Systematic Mapping Study review (SMS) has been conducted. We investigated studies reported from 1993 to 2019 in ScienceDirect library. 4164 articles have been analyzed resulting in 172 primary relevant studies and revealing the treatment of 174 molecules. This paper aims to review the existing and recent trends in techniques for the removal of pharmaceuticals present in varied aqueous matrices and also presents a brief overview of the different classes of pharmaceutical compounds investigated. Findings of this study can help the scientists to identify potential techniques aiming to reduce the impact of pharmaceuticals present in wastewater discharge and into surface water bodies. It was revealed that, antibiotics and analgesics/anti-inflammatories are the most commonly investigated, since the highest risk is posed by these classes. The biological processes were found to be the most commonly used techniques in these field of research, and the diclofenac is the most extensively compounds examined. Recent advances in the field of the combination of AOPs with biological water treatment processes for the degradation of pharmaceuticals are discussed. Finally, advantage and limitations of methods used for the elimination of target compounds are addressed.

即使在低浓度下，地下水和地表水中某些药物化合物的存在也可能构成严重的环境问题。这些化合物的去除是一个趋势广阔的研究主题，它意味着各种各样的学科。为了提供对这一研究领域的清晰见识，已进行了系统制图研究综述（SMS）。我们在ScienceDirect图书馆中调查了1993年至2019年报告的研究。分析了4164篇文章，进行了172项主要相关研究，并揭示了174种分子的治疗方法。本文旨在综述各种水基基质中存在的药物去除技术的现有和最近趋势，并简要概述了所研究的不同类别的药物化合物。这项研究的结果可以帮助科学家确定旨在减少废水排放和地表水体中存在的药物影响的潜在技术。据透露，抗生素和止痛剂/消炎药是最常被研究的，因为这些类别构成最高的风险。在这些研究领域中，发现生物学过程是最常用的技术，而双氯芬酸是研究最广泛的化合物。讨论了AOP与生物水处理工艺相结合用于药物降解的最新进展。最后，解决了用于消除目标化合物的方法的优点和局限性。