Long noncoding RNAs (lncRNAs) act as regulators of gene expression and pivotal transcriptional regulators in cancer cells via diverse mechanisms. lncRNAs involves a variety of pathological and biological activities, such as apoptosis, cell proliferation, metastasis, and invasion. By using microarray and RNA sequencing, it was identified that dysregulation of lncRNAs affects the tumorigenesis process. Taken together, these lncRNAs are putative biomarker and therapeutic target in human malignancies. In this review, I discuss the latest finding regarding the dysregulation of some important lncRNAs and their diverse mechanisms of these lncRNAs in the pathogenesis and progression of certain cancers; also, I summarize the possible roles of lncRNAs in clinical application for diagnosis and prognosis of cancer.

长链非编码 RNA (lncRNA) 通过多种机制在癌细胞中充当基因表达的调节剂和关键的转录调节剂。lncRNAs涉及多种病理和生物学活动，如细胞凋亡、细胞增殖、转移和侵袭。通过使用微阵列和 RNA 测序，发现 lncRNA 的失调会影响肿瘤发生过程。综上所述，这些 lncRNA 是人类恶性肿瘤中公认的生物标志物和治疗靶点。在这篇综述中，我讨论了一些重要的 lncRNA 失调的最新发现，以及这些 lncRNA 在某些癌症的发病机制和进展中的不同机制；此外，我总结了 lncRNA 在癌症诊断和预后的临床应用中的可能作用。