Objective

Atopic diseases worsen with psychological stress, but how stress contributes to their pathogenesis is still not clear. We review the evidence supporting the premise that stress contributes to allergic and inflammatory processes through stimulation of mast cells (MCs) by neuroimmune stimuli.

Data Sources

PubMed was searched between 1950 and 2019 using the following terms: allergies, atopic diseases, corticotropin-releasing hormone, inflammation, hypothalamic-pituitary-adrenal axis, mast cells, mastocytosis, neuropeptides, psychological stress, neurotensin, and substance P.

Study Selections

Only articles published in English were selected based on their relevance to stress and MCs, especially those that discussed potential mechanisms of action.

Results

Psychological stress worsens many diseases, especially asthma, atopic dermatitis, and mastocytosis. This effect is mediated through MCs stimulated by neuropeptides, especially corticotropin-releasing hormone, neurotensin, and substance P, a process augmented by interleukin-33.

Conclusion

Understanding how stress stimulates MCs to release proinflammatory mediators is important in advancing treatments for diseases that worsen with stress.

中文翻译：

---

心理压力对肥大细胞的影响。

目的

特应性疾病会因心理压力而恶化，但尚不清楚压力如何导致其发病。我们审查了支持这一前提的证据，即压力通过神经免疫刺激刺激肥大细胞（MCs）促进了过敏和炎症过程。

数据源

在1950年至2019年之间使用以下术语搜索了PubMed：过敏，特应性疾病，促肾上腺皮质激素释放激素，炎症，下丘脑-垂体-肾上腺轴，肥大细胞，肥大细胞增多症，神经肽，心理压力，神经降压素和P物质。

研究选择

仅根据英文与压力和MC的相关性来选择文章，尤其是那些讨论了潜在作用机制的文章。

结果

心理压力会使许多疾病恶化，尤其是哮喘，特应性皮炎和肥大细胞增多症。这种作用是通过神经肽（尤其是促肾上腺皮质激素释放激素，神经降压素和P物质）刺激的MC介导的，白介素33增强了这一过程。

结论

了解压力如何刺激MC释放促炎性介质对于推进因压力而恶化的疾病的治疗很重要。