Cancer is the second largest killer in the world. Even though the treatment and diagnosis of cancers have increased manifold, the survival rate has not increased proportionately. This discrepancy is mainly due to the toxicity of the chemotherapeutic agents. Natural herbs possessing significant antitumour activity can be utilized to address this issue. Asparagus racemosus is a widely distributed medicinal plant having reported antitumor properties. A concomitant use of the aqueous extract of Asparagus racemous (AEAR) along with Cyclophosphamide (CTX) was studied for the reversal of myelosuppression and hemotoxicity induced by CTX and to test whether AEAR possess significant antitumor activity against Dalton’s Lymphoma Ascites (DLA) tumour in BALB/c mice model. The study consisted of preliminary physico-chemical character determination and phytochemical screening. AEAR was used at 216, 432 and 864 g/kg body weight doses designated as lower, medium and high doses respectively and CTX was used at 25 mg/kg body weight. Hemogram, total leucocyte count, differential leucocyte count, bone marrow cellularity and – esterase positive cells were assessed. Malondialdehyde (MDA), glutathione, superoxide dismutase (SOD) and catalase (CAT) levels were estimated as oxidative stress markers. Tumour volume, size, mean survival time, increase in life span and in vitro cytotoxicity assays involving trypan blue exclusion test and MTT assay were done for antitumor study. AEAR showed significant elevation in hemogram, total leucocyte count, differential count, bone marrow cellularity and -esterase positive cell activity. AEAR at medium and high dose levels showed significant elevation in anti-oxidant enzyme levels of MDA, Glutathione, SOD and CAT enzymes. They also reduced the tumour volume, size and significantly increased the life span and mean survival time of DLA bearing mice. In in vitro cytotoxicity tests also, the medium and high dose of AEAR showed significant cytotoxicity. AEAR at doses of 432 and 864 mg/kg body weight doses significantly reverses the myelosuppression and hemotoxicity. It enhances the levels of antioxidant enzymes and is also an antitumor agent and exerts significant cytotoxicity against DLA tumour cells. Asparagus racemosus provides a ray of hope in addressing the toxicity while using chemotherapeutic agents when used as an adjuvant therapy.

癌症是世界第二大杀手。即使癌症的治疗和诊断增加了很多，但存活率并未成比例地增加。这种差异主要是由于化学治疗剂的毒性所致。具有显着抗肿瘤活性的天然草药可以用来解决这个问题。芦笋芦笋是具有报道的抗肿瘤特性的广泛分布的药用植物。研究了芦笋外消旋水（AEAR）和环磷酰胺（CTX）的同时使用对逆转CTX引起的骨髓抑制和血液毒性的作用，并测试了AEAR是否对BALB的道尔顿淋巴瘤腹水（DLA）肿瘤具有显着的抗肿瘤活性/ c小鼠模型。该研究包括初步的理化特性测定和植物化学筛选。AEAR分别以216、432和864 g / kg体重的剂量使用，分别指定为低，中和高剂量，而CTX则以25 mg / kg体重的剂量使用。评估血流图，总白细胞计数，差异白细胞计数，骨髓细胞和–酯酶阳性细胞。丙二醛（MDA），谷胱甘肽，超氧化物歧化酶（SOD）和过氧化氢酶（CAT）的水平被估计为氧化应激指标。进行了肿瘤体积，大小，平均存活时间，寿命的延长以及涉及锥虫蓝排斥试验和MTT试验的体外细胞毒性试验，用于抗肿瘤研究。AEAR在血象图，总白细胞计数，差异计数，骨髓细胞和酯酶阳性细胞活性方面显示出明显升高。中，高剂量水平的AEAR显示MDA，谷胱甘肽，SOD和CAT酶的抗氧化酶水平显着提高。它们还减少了肿瘤的体积，大小，并显着增加了荷DLA的小鼠的寿命和平均存活时间。同样在体外细胞毒性测试中，中等剂量和高剂量的AEAR也显示出明显的细胞毒性。AEAR的剂量为432和864 mg / kg体重，可显着逆转骨髓抑制和血液毒性。它提高了抗氧化酶的水平，并且还是抗肿瘤剂，并且对DLA肿瘤细胞具有明显的细胞毒性。当芦笋用作辅助治疗剂时，芦笋为解决毒性提供了希望。