Chemical exploration of mangrove-rhizosphere-associated fungus Emericella sp. strain SWR1718 (Aspergillaceae) was performed through various chromatographic workup procedures. The achieved results afforded one new natural compound, emericelactone E (1) in addition to known compounds (2–7). The planar structures of the purified compounds were unambiguously carried out using several spectroscopic methods. Both relative and absolute configurations of compound 1 were carefully determined based on NOESY experiments, coupling constants and comparing its optical rotation with related congeners. Moreover, a plausible biosynthetic pathway of 1 and its related derivatives is reported for the first time in our study. The cytotoxic potential of isolated metabolites was assessed toward three human tumor cell lines where some of them exhibited moderate activities compared to paclitaxel as a standard anticancer.

红树林-根际相关真菌Emericella sp。的化学探索。SWR1718菌株（曲霉）通过各种色谱处理程序进行。所获得的结果，得到一个新的天然化合物，emericelactone E（1除了已知的化合物（）2 - 7）。纯化的化合物的平面结构是使用几种光谱方法明确进行的。化合物1的相对和绝对构型均基于NOESY实验，耦合常数并将其旋光度与相关同类物进行了仔细确定。此外，可能的生物合成途径为1及其相关衍生物首次在我们的研究中报道。评估了分离的代谢物对三种人类肿瘤细胞系的细胞毒性潜力，其中与紫杉醇作为标准抗癌剂相比，其中一些表现出中等活性。