Objective

Diabetes mellitus (DM) is a metabolic illness and it is a result of hyperglycemia ensuing since a deficiency in insulin production, insulin function. Based on WHO statistics, more than 347 million peoples are suffered from the DM globally and it may increase to 694 million in 2030. Vanillic acid (VA) is a phenolic derived compound from dietary vegetations and fruits with the many biological acitivities. This current research was planned to investigate the antidiabetic and anti-inflammatory potential of VA on streptozotocin-challenged DM in rats.

Methods

Later than an overnight fast, the rats were induced diabetes via one intraperitoneal treatment of STZ (40 mg/kg b.wt) in a newly organized 0.1 M citrate buffer. We analyzed body weight, plasma glucose, liver marker enzymes, insulin, carbohydrate metabolic enzymes, glycosylated hemoglobin, protein profiles, oxidant/antioxidant levels, inflammatory mediators and also evaluate histopathology of pancreatic tissues in normal control and investigational animals.

Results

Diabetic animals were revealed an increased in HbA1c, blood glucose, food and fluid intake and relative weight of kidney and liver, whereas the reduced level of insulin and body weight. Furthermore, augmented levels of ALT, glucose-6-phosphatase, AST, TBARS, TNF-α, creatinine, LOOH, fructose 1,6-bisphosphatase, ALP, IL-6 and IL-1β whereas, reduced status of antioxidant enzymes were observed in diabetic rats. Histopathological analysis of pancreatic tissues was in support of the biochemical parameters.

Conclusions

Diabetic rats treated by VA significantly alter all these parameters toward normal levels. These results recommended that the VA is a potential antidiabetic and anti-inflammatory effect for the cure of DM.

中文翻译：

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香草酸改善链脲佐菌素诱导的糖尿病大鼠的高血糖诱导的氧化应激和炎症

目的

糖尿病（DM）是一种代谢性疾病，是由于胰岛素生产，胰岛素功能不足引起的高血糖症的结果。根据WHO的统计数据，全球有DM人口超过3.47亿，到2030年可能会增加到6.94亿。香草酸（VA）是一种酚类化合物，来源于饮食植物和水果，具有许多生物活性。计划进行这项当前的研究，以研究VA对链脲佐菌素激发的DM大鼠的抗糖尿病和抗炎作用。

方法

禁食过夜后，通过在新组织的0.1 M柠檬酸盐缓冲液中腹腔内给予STZ（40 mg / kg b.wt）进行一次大鼠诱发糖尿病。我们分析了体重，血浆葡萄糖，肝标志物酶，胰岛素，碳水化合物代谢酶，糖基化血红蛋白，蛋白质谱，氧化剂/抗氧化剂水平，炎症介质，并评估了正常对照和研究动物的胰腺组织病理学。

结果

糖尿病动物体内的HbA1c，血糖，食物和液体摄入量以及肾脏和肝脏的相对重量增加，而胰岛素和体重却降低。此外，ALT，葡萄糖-6-磷酸酶，AST，TBARS，TNF-α，肌酐，LOOH，果糖1,6-双磷酸酶，ALP，IL-6和IL-1β的水平升高，而抗氧化酶的状态降低在糖尿病大鼠中。胰腺组织的组织病理学分析支持生化参数。

结论

VA治疗的糖尿病大鼠将所有这些参数显着改变至正常水平。这些结果表明，VA对糖尿病的治疗具有潜在的抗糖尿病和抗炎作用。