Introduction

Progesterone has been implicated as protective against drug taking behaviors, including combustible cigarettes. While prior research indicates higher endogenous progesterone levels are associated with a reduction in smoking intensity (as measured by smoking topography), it is unknown if exogenous delivery of progesterone may have the same effect.

Methods

This double-blind, counterbalanced, cross-over randomized trial enrolled women between the ages of 18 and 40 who smoked at least five cigarettes per day and were currently using oral contraceptives. After overnight abstinence participants attended two topography lab sessions. One lab session was conducted during progesterone (200 mg twice per day) treatment and the other was during placebo treatment. Analyses included linear mixed effect models to examine the effect of exogenous progesterone administration and endogenous progesterone values on topography outcomes.

Results

Participants (n = 43) were 23.8 (standard deviation [SD] ± 4.5) years old, smoked 10.5 (SD ± 3.7) cigarettes per day. Compared to placebo administration, progesterone administration reduced cumulative puff volume by 300 mL (95% confidence interval [CI]: −536, −65; p-value = 0.01) with additional trends indicating possible reductions in the number of puffs, average puff volume, and average flow. There were no significant effects of endogenous progesterone on smoking topography outcomes.

Conclusions

Progesterone administration has the potential to reduce smoking intensity after overnight abstinence in women of reproductive age. Additional research is needed to explore how this may relate to smoking cessation outcomes in women of reproductive age.

中文翻译：

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外源性黄体酮给药对吸烟地形的影响。

介绍

黄体酮被认为可以防止吸毒行为，包括可燃香烟。虽然先前的研究表明较高的内源性黄体酮水平与吸烟强度的降低有关（通过吸烟地形测量），但不知道外源性黄体酮是否可能具有相同的效果。

方法

这项双盲、平衡、交叉随机试验招募了年龄在 18 至 40 岁之间的女性，她们每​​天至少抽五支烟，目前正在使用口服避孕药。经过一夜禁欲，参与者参加了两次地形实验室会议。一个实验室会话是在黄体酮（每天两次 200 毫克）治疗期间进行的，另一个是在安慰剂治疗期间进行的。分析包括线性混合效应模型，以检查外源性孕酮给药和内源性孕酮值对地形结果的影响。

结果

参与者 (n = 43) 为 23.8 (标准差 [SD] ± 4.5) 岁，每天吸 10.5 (SD ± 3.7) 支香烟。与安慰剂给药相比，黄体酮给药使累积抽吸量减少了 300 mL（95% 置信区间 [CI]：-536，-65；p 值 = 0.01），另外的趋势表明抽吸次数、平均抽吸量可能减少, 和平均流量。内源性黄体酮对吸烟地形结果没有显着影响。

结论

孕激素给药有可能降低育龄妇女夜间戒烟后的吸烟强度。需要进行更多研究来探索这与育龄妇女戒烟结果之间的关系。