Background

Credible research emphasizes transparency, openness, and reproducibility. These characteristics are fundamental to promoting and maintaining research integrity. The aim of this study was to evaluate the current state of reproducibility in the field of addiction science.

Design

Cross-sectional design.

Measurements

The National Library of Medicine catalog was searched for all journals using the subject terms tag: Substance-Related Disorders [ST]. Journals were then searched via PubMed to identify publications from January 1, 2014, to December 31, 2018; 300 publications were randomly selected from among those identified. A pilot-tested Google form containing reproducibility/transparency characteristics was used for data extraction in a duplicated and blinded fashion by two investigators.

Findings

Slightly more than half of the publications were open access (152/300, 50.70%). Few publications had pre-registration (7/244, 2.87%), material availability (2/237, 0.84%), protocol availability (3/244, 1.23%), data availability (28/244, 11.48%), or analysis script availability (2/244, 0.82%). Most publications provided a conflict of interest statement (221/293, 75.43%) and funding sources (268/293, 91.47%). One replication study was reported (1/244, 0.4%).

Conclusion

Our study found that current practices that promote transparency and reproducibility are lacking, thus, there is room for improvement. In particular, investigators should pre-register studies prior to commencement. Researchers should also make the materials, data, and analysis script publicly available. Further, individuals should be transparent about funding sources for the project and financial conflicts of interest. Research stakeholders should work together toward improvements on these matters. With such protections, the field of addiction medicine can better disseminate the information necessary to treat patients.

中文翻译：

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对成瘾医学文献中的透明度和可重复性实践的评估。

背景

可信的研究强调透明度，开放性和可重复性。这些特征是促进和保持研究完整性的基础。这项研究的目的是评估成瘾科学领域中的可再现性现状。

设计

横断面设计。

测量

使用主题词标签：与药物相关的疾病[ST]在国家医学图书馆的目录中进行搜索。然后通过PubMed搜索期刊，以识别从2014年1月1日到2018年12月31日的出版物；从确定的出版物中随机选择300种出版物。两位研究人员以重复和盲目的方式，使用了包含可重复性/透明性特征的经过Google测试的Google表单，以重复和盲目的方式提取了数据。

发现

略有一半以上的出版物是开放获取的（152 / 300，50.70％）。很少有出版物具有预注册（7/244，2.87％），材料可用性（2/237，0.84％），协议可用性（3/244，1.23％），数据可用性（28/244，11.48％）或分析脚本可用性（2 / 244，0.82％）。大多数出版物提供了利益冲突声明（221/293，占75.43％）和资金来源（268 / 293，91.47％）。据报道有一项复制研究（1 / 244，0.4％）。

结论

我们的研究发现，目前缺乏提高透明度和可重复性的实践，因此还有改进的空间。特别是，研究人员应在开始研究之前预先注册研究。研究人员还应公开提供材料，数据和分析脚本。此外，个人应该对项目的资金来源和财务利益冲突保持透明。研究利益相关者应共同努力，以改善这些问题。通过这种保护，成瘾医学领域可以更好地传播治疗患者所需的信息。