The aim of this special issue was to investigate the mechanisms behind China’s innovation ecosystem by viewing the key participants at multi-level: firms, research institutes, universities, intermediaries, supply-chain systems, governments and so forth. There were interesting threads connecting research on innovation participants throughout the submitted papers. Briefly, the following topics were addressed: 1. evaluation of China’s innovation performance at a regional (provincial) level and recognition of successful practices as well as problem issues; 2. the influence at a micro level of uniquely Chinese factors on firms’ innovation performance - for instance, how has the regulatory context (e.g., state ownership, industry policy) shaped corporate innovation activities? 3. the relative importance of government and industry support mechanisms; 4. the roles of Chinese state research institutes and the significance of their network positions (e.g. structural hole and centrality) on innovation performance.