Major histocompatibility complex (MHC) molecules bind peptides originated from cellular synthesis and present them at the cell surface for recognition by receptors on immune cells like T lymphocytes, natural killer (NK) cells or mast cells. Such recognition plays a crucial part in autoimmunity, anti-bacterial, anti-viral and anti-tumor responses. Human leukocyte antigen G (HLA-G) is a member of non-classical HLA class I molecules which has been studied deeply in recent years into its role in pregnancy and endometrial diseases, including endometrial tumor, endometriosis and adenomyosis, etc. Understanding the mechanism of the maintenance of pregnancy and immune escape of endometrial diseases in a HLA-G dependent way is of current interest. Perception from studies in the expression of HLA-G and possible pathways is a vital part of understanding mechanisms related to immune escape.

主要组织相容性复合物 (MHC) 分子结合源自细胞合成的肽，并将其呈现在细胞表面，以供 T 淋巴细胞、自然杀伤 (NK) 细胞或肥大细胞等免疫细胞上的受体识别。这种识别在自身免疫、抗菌、抗病毒和抗肿瘤反应中起着至关重要的作用。人类白细胞抗原 G (HLA-G) 是非经典 HLA I 类分子的成员，近年来对其在妊娠和子宫内膜疾病中的作用进行了深入研究，包括子宫内膜肿瘤、子宫内膜异位症和子宫腺肌病等。 了解机制以 HLA-G 依赖性方式维持妊娠和子宫内膜疾病的免疫逃逸的研究是当前的兴趣所在。