Sera 17β-estradiol (E2), 11-ketotestesteron (11-KT) and 17,20-β-dihydroxy-4-pregnen-3-one (17,20βP) levels together with histological changes in liver and gonad tissues were determined after exposing sexually mature female C.carpio to 0.13 and 0.26 mg L^− 1 lead for 7, 14 and 21 days. Effects of lead on hepatosomatic - gonadosomatic indices of female fish were also determined after these exposure periods. No statistically significant differences were found between the E2, 11-KT and 17,20βP levels of control and lead exposed fish at the exposure periods tested. GSI values increased after exposure to high levels of Pb for 14 days and HSI values decreased after exposure to high levels of Pb after 7 and 21 days. Histopathological inspection showed dilatation in bile ducts and sinusoids, central vein congestions and pigment accumulation. Moreover melanomacrophage centres were determined in the centre of liver parenchyma on day 21. No distinct pathology was observable in ovary tissues compared to controls. No endocrine disrupted characteristic, widespread pathologic disruption and effect on ovary tissues were detected in female C.carpio exposed to the mentioned concentrations of Pb at the periods studied.

确定血清17β-雌二醇（E2），11-酮睾酮（11-KT）和17,20-β-二羟基-4-孕烯-3-酮（17,20βP）水平以及肝脏和性腺组织的组织学变化使性成熟的雌性鲤鱼暴露于0.13和0.26 mg L ^{− 1下}领先7、14和21天。在这些暴露时间之后，还确定了铅对雌鱼肝体-性腺体指数的影响。在测试的暴露时间，对照组和铅暴露鱼的E2、11-KT和17,20βP水平之间没有发现统计学上的显着差异。暴露于高含量的Pb 14天后GSI值增加，而暴露于高含量的Pb 7天和21天后HSI值降低。组织病理学检查显示胆管和窦道扩张，中心静脉充血和色素积聚。此外，在第21天，在肝实质的中心确定了黑色素巨噬细胞中心。与对照相比，在卵巢组织中没有观察到明显的病理。没有内分泌紊乱的特征，在研究期间，鲤鱼暴露于上述浓度的铅。